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Oxycodone is a semisynthetic opioid synthesized from thebaine, an opioid alkaloid found in the Persian poppy, and one of the many alkaloids found in the opium poppy. It is a moderately potent opioid analgesic, generally indicated for the relief of moderate to severe pain. Oxycodone is available as single-ingredient medication in immediate release and controlled release(intended to be taken every 12 hours). A 2006 review found that controlled-release oxycodone is comparable to instant release oxycodone, morphine, and hydromorphone in the management of moderate to severe cancer pain, with fewer side effects than morphine.
Oxycodone is used for managing moderate to moderately severe acute or chronic pain. It has been found to improve the quality of life for those with many types of pain. It is also used in the management of moderate to severe cancer pain. The controlled release form is a valid alternative to morphine and a first-line treatment for cancer pain. Oxycodone, like other opioid analgesics, tends to induce feelings of euphoria, relaxation, and reduced anxiety in those who are occasional users. This makes it one of the most commonly abused pharmaceutical drugs in the U.S.
Common side effects of oxycodone include constipation, nausea, vomiting, somnolence, dizziness, itching, dry mouth, and sweating. Less common side effects include loss of appetite, nervousness, abdominal pain, diarrhea, urine retention, dyspnea, and hiccups.
In high doses, or in some persons not tolerant to opioids, oxycodone can cause shallow breathing, slowed heart rate, cold/clammy skin, pauses in breathing, low blood pressure, constricted pupils, circulatory collapse, respiratory arrest, and death.
Oxycodone overdose has also been described to cause spinal cord infarction in high doses and ischemic damage to the brain, due to prolonged hypoxia from suppressed breathing.
The symptoms of oxycodone withdrawal, as with other opioids, may include “anxiety, panic attack, nausea, insomnia, muscle pain, muscle weakness, fevers, and other flu-like symptoms”.
Chronic use of oxycodone (particularly with higher doses) often causes concurrent hypogonadism or hormone imbalance.
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